3,881 research outputs found
Snow-air interactions and management of mountain watershed snowpack,
Includes bibliographical references.OWRR Project no. B-073-COLO
Recommended from our members
Competitor analysis of functional group H-bond donor and acceptor properties using the Cambridge Structural Database.
Intermolecular interactions found in the Cambridge Structural Database (CSD) are analysed as the outcomes of competitions between the different functional groups that are present in each structure: the most energetically favourable interactions are expected to win more often than weaker interactions. Tracking winners and losers through each crystal structure in the CSD provides data that can be analysed using paired comparison algorithms to rank functional group H-bonding properties based on how frequently they outcompete other functional groups in the crystal. This treatment is superior to simple statistical analyses of whether functional groups H-bond or not, because the distribution of H-bond donors and acceptors in the structures of the molecules found in the CSD is non-random. Most organic molecules contain more acceptors than donors, so that all H-bond donors are almost always H-bonded in all crystal structures, and most acceptors are not. The rankings of H-bond acceptors obtained by applying the TrueSkill paired comparison algorithm to the CSD agree well with the corresponding experimentally determined solution phase H-bond acceptor parameters β, but there is insufficient data to corroborate H-bond donor rankings calculated in the same way. The method is used to make predictions of the H-bond acceptor properties of functional groups for which solution phase measurements are not available.Engineering and Physical Sciences Research
Council, Cambridge Crystallographic Data Centr
Maternal prenatal mental health and placental 11β-HSD2 gene expression: initial findings from the mercy pregnancy and emotional wellbeing study
High intrauterine cortisol exposure can inhibit fetal growth and have programming effects for the child\u27s subsequent stress reactivity. Placental 11beta-hydroxysteroid dehydrogenase (11β-HSD2) limits the amount of maternal cortisol transferred to the fetus. However, the relationship between maternal psychopathology and 11β-HSD2 remains poorly defined. This study examined the effect of maternal depressive disorder, antidepressant use and symptoms of depression and anxiety in pregnancy on placental 11β-HSD2 gene (HSD11B2) expression. Drawing on data from the Mercy Pregnancy and Emotional Wellbeing Study, placental HSD11B2 expression was compared among 33 pregnant women, who were selected based on membership of three groups; depressed (untreated), taking antidepressants and controls. Furthermore, associations between placental HSD11B2 and scores on the State-Trait Anxiety Inventory (STAI) and Edinburgh Postnatal Depression Scale (EPDS) during 12-18 and 28-34 weeks gestation were examined. Findings revealed negative correlations between HSD11B2 and both the EPDS and STAI (r = -0.11 to -0.28), with associations being particularly prominent during late gestation. Depressed and antidepressant exposed groups also displayed markedly lower placental HSD11B2 expression levels than controls. These findings suggest that maternal depression and anxiety may impact on fetal programming by down-regulating HSD11B2, and antidepressant treatment alone is unlikely to protect against this effect
Infrared constraints on the dark mass concentration observed in the cluster Abell 1942
We present a deep H-band image of the region in the vicinity of the cluster
Abell 1942 containing the puzzling dark matter concentration detected in an
optical weak lensing study by Erben et al. (2000). We demonstrate that our
limiting magnitude, H=22, would be sufficient to detect clusters of appropriate
mass out to redshifts comparable with the mean redshift of the background
sources. Despite this, our infrared image reveals no obvious overdensity of
sources at the location of the lensing mass peak, nor an excess of sources in
the I-H vs. H colour-magnitude diagram. We use this to further constrain the
luminosity and mass-to-light ratio of the putative dark clump as a function of
its redshift. We find that for spatially-flat cosmologies, background lensing
clusters with reasonable mass-to-light ratios lying in the redshift range 0<z<1
are strongly excluded, leaving open the possibility that the mass concentration
is a new type of truly dark object.Comment: 8 pages, 7 figures. MNRAS submitted (after referee revision
Alkaloid inspired spirocyclic oxindoles from 1,3-dipolar cycloaddition of pyridinium ylides
Cycloaddition reactions between pyridinium ylides and 3-alkenyl oxindoles that proceed in high yield and with very good regio- and diastereoselectivity are reported. The resulting cycloadducts have the same stereochemistry of biologically active oxindole alkaloids, such as strychnofoline
Blacks in Massachusetts: Comparative Demographic, Social and Economic Experiences with Whites, Latinos, and Asians
This report describes the social and economic, and education status of Blacks in Massachusetts, within a comparative framework with Whites, Asians, and Latino/as. A range of population, household, and economic variables are highlighted under the following categories: Population Characteristics; Families and Households; Education and Schooling; Housing; Health Characteristics; Labor Force, Occupations and Employment; and Income and Poverty. The information presented in this report is based on data from the 2010 Decennial Census; the American Community Survey 2009 – 2013 5 Year Estimates; the American Community Survey 2009-2013 5-Year Estimates Public Use Microdata Sample (PUMS) as well as PUMS for the single year 2013; and the Current Population Survey’s Annual Social and Economic Supplement (2015), and other CPS reports
Promoting Clinical Engagement and Cross-sector Collaboration Through Changes in Workforce, Use of Technology, and Improved Business Systems
Published version made available here with permission from publisher.Background: Cross-sectoral collaboration across health care settings has the potential to
deliver efficiencies as well as improve health care outcomes. There is a need for better
understanding and awareness of models, mechanisms and strategies that enhance crosssectoral
collaboration in Australia. Improved cross-sectoral collaboration is supported by a
number of changes in workforce, use of technology and improved business systems. This
review seeks to summarise these programs for those who may be seeking to engage in this
area as a means of determining the range of options and possible proven benefits.
Methodology: This study employs a mixed methods approach. A pragmatic literature review
was undertaken to determine the relevant collaborative care models and review current
programs Australia-wide that implement these models. Programs were selected from
searching the grey and indexed medical literature as well as suggestions obtained from
relevant stakeholders. Criteria for inclusion included having description in the peer reviewed
and grey literature, ability to represent a unique model, extent of current use and description of
outcomes of the intervention. Additional qualitative semi-structured interviews were conducted
to elucidate more detailed information about technology, workforce and business systems.
This information is summarised in the report and details about the individual programs are
included as an appendix to this report.
Results: Fifteen models were reviewed for this report. Qualitative semi-structured interview
data were employed to supplement findings from the literature review. Key mechanisms of
these models are described specifically focusing on the use of technology, workforce and
business systems. Facilitators and barriers were identified and explored
- …